Parkinsonian signs and substantia nigra neuron density in decendents elders without PD
Identifieur interne : 001591 ( Main/Exploration ); précédent : 001590; suivant : 001592Parkinsonian signs and substantia nigra neuron density in decendents elders without PD
Auteurs : G. Webster Ross [États-Unis] ; Helen Petrovitch [États-Unis] ; Robert D. Abbott [États-Unis] ; James Nelson [États-Unis] ; William Markesbery [États-Unis] ; Daron Davis [États-Unis] ; John Hardman [États-Unis] ; Lenore Launer [États-Unis] ; Kamal Masaki [États-Unis] ; Caroline M. Tanner [États-Unis] ; Lon R. White [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 2004-10.
Abstract
Substantia nigra (SN) neurons were counted on single, transverse caudal midbrain sections from 217 male participants in the Honolulu‐Asia Aging Study, aged 74–97 years at death. Quadrants areas within the SN were determined with a planimeter and neuronal density was expressed as neurons/mm2 for 10 Parkinson's disease (PD) cases, 29 incidental Lewy body cases, and 178 controls with neither condition. Mean densities in all quadrants were significantly lower in the PD group compared with the other groups (p = 0.006). This relationship was strongest in the ventrolateral quadrant. In a subgroup of 50 controls who were examined with the Unified Parkinson's Disease Rating Scale an average of 2.1 years prior to death, there was an association of stooped posture (p = 0.009), postural instability (p = 0.013), body bradykinesia (p = 0.048), and gait disturbance (p = 0.05) with neuron density in the dorsolateral quadrant; and impaired speech (p = 0.014), abnormal facial expression (p = 0.022), and difficulty rising from a chair (p = 0.032) with neuron density in the dorsomedial quadrant. There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD. Ann Neurol 2004
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DOI: 10.1002/ana.20226
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Burns School of Medicine, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Markesbery, William" sort="Markesbery, William" uniqKey="Markesbery W" first="William" last="Markesbery">William Markesbery</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>Sanders‐Brown Center on Aging, University of Kentucky Medical Center, Lexington</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>Department of Pathology, University of Kentucky Medical Center, Lexington</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>Departments of Neurology, University of Kentucky Medical Center, Lexington</wicri:cityArea></affiliation></author><author><name sortKey="Davis, Daron" sort="Davis, Daron" uniqKey="Davis D" first="Daron" last="Davis">Daron Davis</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>Department of Pathology, University of Kentucky Medical Center, Lexington</wicri:cityArea></affiliation></author><author><name sortKey="Hardman, John" sort="Hardman, John" uniqKey="Hardman J" first="John" last="Hardman">John Hardman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Department of Pathology, University of Hawaii, John A. 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Burns School of Medicine, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Honolulu Department of Veteran's Affairs, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Honolulu‐Asia Aging Study, Kuakini Medical Center, Honolulu</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-10">2004-10</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="532">532</biblScope><biblScope unit="page" to="539">539</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">EA7BEFF5C67BB6FF72D009B1B9B53E587262E91D</idno><idno type="DOI">10.1002/ana.20226</idno><idno type="ArticleID">ANA20226</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Substantia nigra (SN) neurons were counted on single, transverse caudal midbrain sections from 217 male participants in the Honolulu‐Asia Aging Study, aged 74–97 years at death. Quadrants areas within the SN were determined with a planimeter and neuronal density was expressed as neurons/mm2 for 10 Parkinson's disease (PD) cases, 29 incidental Lewy body cases, and 178 controls with neither condition. Mean densities in all quadrants were significantly lower in the PD group compared with the other groups (p = 0.006). This relationship was strongest in the ventrolateral quadrant. In a subgroup of 50 controls who were examined with the Unified Parkinson's Disease Rating Scale an average of 2.1 years prior to death, there was an association of stooped posture (p = 0.009), postural instability (p = 0.013), body bradykinesia (p = 0.048), and gait disturbance (p = 0.05) with neuron density in the dorsolateral quadrant; and impaired speech (p = 0.014), abnormal facial expression (p = 0.022), and difficulty rising from a chair (p = 0.032) with neuron density in the dorsomedial quadrant. There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD. Ann Neurol 2004</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Hawaï</li><li>Kentucky</li><li>Maryland</li><li>Virginie</li></region></list><tree><country name="États-Unis"><region name="Hawaï"><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name></region><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name><name sortKey="Davis, Daron" sort="Davis, Daron" uniqKey="Davis D" first="Daron" last="Davis">Daron Davis</name><name sortKey="Hardman, John" sort="Hardman, John" uniqKey="Hardman J" first="John" last="Hardman">John Hardman</name><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name><name sortKey="Markesbery, William" sort="Markesbery, William" uniqKey="Markesbery W" first="William" last="Markesbery">William Markesbery</name><name sortKey="Markesbery, William" sort="Markesbery, William" uniqKey="Markesbery W" first="William" last="Markesbery">William Markesbery</name><name sortKey="Markesbery, William" sort="Markesbery, William" uniqKey="Markesbery W" first="William" last="Markesbery">William Markesbery</name><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name><name sortKey="Nelson, James" sort="Nelson, James" uniqKey="Nelson J" first="James" last="Nelson">James Nelson</name><name sortKey="Nelson, James" sort="Nelson, James" uniqKey="Nelson J" first="James" last="Nelson">James Nelson</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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